HORDB

ID: hor003259
Uniprot ID: Q95104
Protein name: Leu-enkephalin
Gene name: PDYN
Organism: Bos taurus (Bovine)
Family: Opioid neuropeptide precursor family
Source: animal
Expression: pituitary gland,striatum and hypothalamus
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity; GO:0031628 opioid receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
GO CC: GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus

Sequence: YGGFL
Length: 5(175-179)
Propeptide: MVWQGLVLAACLLALPSVTADCLAQCSLCAVKTQDGPQPINPLVCSLECQAALQPAQEWERCQGLLSFLTPFTVGLNGKEDLKSKTVLEESSSEPAKHIRPYLKELEKNRFLLSTPAEKNALSSSLVEKLRGLSGRLGEDAESELMGDAQLNDGALEAEARDSNEEEPKEQVKRYGGFLRKYPKRSSEVTGKEAGEGEGGEVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPSAYYEEL
Signal peptide: MVWQGLVLAACLLALPSVTA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress
Mechanism: NA
Cross BBB: YES
Target: OPRM1
Target Unid: P79350
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 21.2卤1.1 minute; /1272 seconds ( PubMed ID: 12444298 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003259_AF2.pdb

hor003259_ESM.pdb

Mass:	62716	Formula:	C28H37N5O7
Absent amino acids:	ACDEHIKMNPQRSTVW	Common amino acids:	G
pI:	6.09	Basic residues:	0
Polar residues:	3	Hydrophobic residues:	2
Hydrophobicity:	90	Boman Index:	964
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	78
Instability Index:	1570	Extinction Coefficient cystines:	1490
Absorbance 280nm:	372.5